منابع مشابه
Vitamin D and colon carcinogenesis.
Colorectal cancer is the third most commonly occurring cancer in the United States and accounts for approximately 11% of cancer deaths. Many epidemiological studies have shown an association between dietary factors, including calcium and vitamin D, and the incidence of colon cancer. Recently the Calcium Polyp Prevention Study demonstrated that calcium supplementation can reduce the recurrence o...
متن کاملSynergistic effect of vitamin E and selenium in the chemoprevention of mammary carcinogenesis in rats.
The present study showed that vitamin E, although ineffective by itself, was able to potentiate the ability of selenium to inhibit the development of mammary tumors induced by dimethylbenz(a)anthracene (DMBA) in rats. Animals were maintained on a high-polyunsaturated fat (20% corn oil) diet in order to increase the degree of oxidant stress; additional selenium and/or vitamin E were present at a...
متن کاملChemopreventive effects of early-stage and late-stage supplementation of vitamin E and selenium on esophageal carcinogenesis in rats maintained on a low vitamin E/selenium diet.
Low vitamin E and selenium (Ve/Se) nutritional status is known to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). A previous human intervention trial demonstrated that Ve/Se supplementation decreased the occurrence of esophageal cancer death among younger participants but not among older ones. In this study, we intended to mimic this human nutritional status to d...
متن کاملVitamin E Supplementation in Chemical Colorectal Carcinogenesis: A Two-Edged Knife
This work investigated the effects of Vitamin E (VE) on aberrant crypt foci (ACF) incidence, oxidative stress parameters (serum and hepatic VE concentration, and homocysteine, glutathione (GSH), and malondialdehyde (MDA) levels), and expression of both cyclooxygenase-2 (COX2) and proliferating cellular nuclear antigen (PCNA) in experimental colorectal carcinogenesis. Male Wistar rats received s...
متن کاملInhibitory effect of vitamin A on carcinogenesis.
In two experiments, f3-carotene applied to mice initiated with 7,12-dimethylbenz[a]anthracene (DMBA), concomitantly with croton resin and croton oil, increased tumor incidence by 58 and 29%. In the same experiments, retinyl acetate reduced tumor incidence by 76 and 29%. Retinol in one experiment reduced the number of papillomas by 75%. f3-lonone, squalene, and isoprene had little or no effect o...
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ژورنال
عنوان ژورنال: Journal of Toxicologic Pathology
سال: 1994
ISSN: 0914-9198,1881-915X
DOI: 10.1293/tox.7.179